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IBS Research- comments below each article


Gastroenterology. 2007 Mar;132(3):913-20.http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?itool=AbstractPlus-def&PrId=3048&uid=17383420&db=pubmed&url=http://linkinghub.elsevier.com/retrieve/pii/S0016-5085(07)00185-0  

Immune activation in patients with irritable bowel syndrome

Researchers test the hypothesis that irritable bowel syndrome is characterized by a cellular immune response with the production of proinflammtory cytokines and also explore psychiatric symptoms associated with IBS.  IBS-D patients who had greater than 3 bowel movements per day with watery stools, pain and cramping showed significantly higher cytokine levels in all categories, with accompanying anxiety. 
 
***Cytokine activation is indicative of an immune response:
It's not all in your head

  Gut 1996 Jul; 39(1) 130-5

Double blind, placebo controlled food reactions do not correlate to IgE allergy in the diagnosis of staple food related gastrointestinal symptoms

In this study, they took patients who exhibited gastrointestinal symptoms in response to foods and did blinded challenge of thes patients along with skin prick testin and RAST testing, classic measures of IgE sensitivities and for the control and atopic group there was no evidence that IgE or classic allergies were involved, suggesting other immune mechanisms were at play.  

**The immune reaction is not your classic IgE or Allergic Reaction


Am J Gastroenterol. 2005 Jul;100(7):1558-9

IgG-mediated food intolerance in irritable bowel syndrome: a real phenomenon or an epiphenomenom?

 Shows mediocre results emerging from disease management that relies on the old method of IgG testing to detect sensitivities but hints that foods do play a role)  Right idea, wrong, testing.


Dis Manag Advis.2004 Jan;10(1):6-10, 1. Links

Alternative approach to IBS and migraine is winning over providers.  (a description of the LEAP Program's successes in pinpointing triggers for IBS, migraine and even the more delayed and enigmatic fibromyalgia)




Am J Gastroenterol 2000 Jan;95(1):157-65

- Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities. Locke GR 3rd, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ